Improvements in exercise capacity are associated with decreased mortality among pre-hypertensive men, data show.
Researchers led by Peter Kokkinos, PhD,
Director of the Exercise Testing and Research Lab at the Veterans
Affairs Medical Center and a professor in the Division of Cardiology at
Georgetown University Medical Center in Washington, D.C., examined the
association between peak exercise capacity (measured as metabolic
equivalent tasks [METs]) and mortality in a group of 4,735
pre-hypertensive men.
METs represent the energy expenditure
requirement for various activities. The more vigorous an activity, the
greater the number of METs required.
Subjects were divided into four fitness
categories: those who achieved less than 5, 5-7, 7.1-10, and more than
10 METs. Over 22 years of follow-up (mean 8.0 years), 943 deaths
occurred. After adjusting for age, BMI, diabetes, and dyslipidemia,
exercise capacity was the strongest risk factor for mortality,
according to findings presented at the American Society of Hypertension
annual meeting in San Francisco. Each 1-MET increase in exercise
capacity was associated with a 14% decreased risk of death overall and
an 18% and 11% decreased risk among men younger and older than 60,
respectively.
Compared with men who achieved 5 METs,
those who achieved 5-7, 7.1-10, and more than 10 METs had a 25%, 60%,
and 75% decreased risk of death.
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